Technische Universität München

The Entrepreneurial University

An adverse effect concerning the skeletal muscle can be seen in glycogenolysis, which is mediated by epinephrine via stimulation of beta-2 receptors. During submaximal exercise muscle glycogenolysis is unaffected, but the maximal glycogenolytic rate at high exercise intensities is decreased. Adverse effects of beta-blockers can be observed at an overdose or an abuse in healthy persons mainly located in the cardiovascular system.