Technische Universität München

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Morphine frequently causes side-effects such as hyperhydrosis and facial flushing. The best known skin disorders are urticaria, erythema, and itching (pruritus); sometimes pseudoallergic anaphylactoid reactions and blisters have also been reported. Morphine has further side-effects on the skin like the inhibition of nociceptors of skin under inflammation conditions.
Codeine can produce itching (pruritus). Ablate delayed hypersensitive skin response could be derivated in immunological problems.
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