Technische Universität München

The Entrepreneurial University

Glucocorticosteroids (GCs) present severe side effects and risks on muscles, tendons and ligaments: starting with osteoporosis and the increased risk of fractures and a delayed bone repair up to a decrease in muscle nutrition and a severe risk of muscle atrophy. The adverse effects of GCs can be compared to those of the anabolic steroids due to the affiliation of GCs to catabolic hormones. For instance, long-term abuse of glucocorticoids or a clinically use as therapy is associated with loss of bone and muscle mass. The trigger of this effects is a inhibited bone metabolism. Adverse effects like atrophies of tendon and ligaments were also reported in animal studies and case studies of humans.