Technische Universität München

The Entrepreneurial University

The side effects of hormone antagonists and modulators on male reproductive system are not well known. In women SERMs treatment (tamoxifen) may result in irregular periods, vaginal irritation, proliferation of the endometrium, uterine bleeding, and increased risks of endometrial cancer and uterine sarcoma. The adverse effects of clomiphene treatment on the female reproductive system include ovarian enlargement with pelvic or abdominal pain and uterine bleeding.