Technische Universität München

The Entrepreneurial University

Some diuretics (thiazides, loop diuretics) can raise blood sugar, triglyceride and cholesterol levels. Thiazide diuretics have been reported to cause erectile dysfunctions and decreased libido by an unknown mechanism.
Spironolactone is an aldosterone antagonist, potassium-sparing diuretic. Due to its steroid structure it can cause antiandrogen effects such as impotence, decreased libido and gynaecomastia in men as well as menstrual irregularities including amenorrhea in women. In addition spironolactone has been shown to be a tumorigen in studies performed in rats, with its proliferative effects manifested on endocrine organs and the liver.