Technische Universität München

The Entrepreneurial University

The spectrum of side-effects can be ascribed decisively on changes in the electrolyte balance. Thus, thiazides cause sodium and calcium lack and loop diuretics a potassium and calcium lack. The osmotic diuretics lead to a sodium lack, too. Potassium-saving diuretics and aldosterone antagonists cause, like the name expresses, a potassium profit.
While sodium lack releases a strong thirst feeling, which disturbs sensations of taste and can release cramps also in the upper abdomen, a potassium lack leads to inertness of the intestinal musculature. Calcium lack can also cause indigestion. Calcium has a pivotal function for the transfer of the electrical impulses in the ENS. In summary, sodium, potassium and calcium levels are the decisive factors which determine the side-effect spectrum.