Technische Universität München

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The accelerating effect of high protein consumption in the process of chronic renal failure has been well known for many years. Weightlifters and body-builders often experience a rise in serum creatinine as a result of increased skeletal muscle mass. On the other hand, AAS use may elevate serum creatinine levels, blood urine nitrogen and uric acid. The combination of AAS and creatine supplement may also cause severe renal damage. A case of severe nephrotic syndrome with diffuse membrano-proliferative glomerulonephritis in an athlete using AASs and creatine for a long time has been reported.
Wilm’s tumor, uncommon in adults has been found in several athletes using AAS. Furthermore, steroids are weak carcinogens that can initiate tumor growth or promote such growth in the presence of other carcinogens. It is suggested that the long-term use of AAS should be at least considered as an etiologic factor for renal cell carcinoma occurrence.
There are only a few studies indicating a potential linkage between the use of AAS and acute renal failure (ARF). Abuse of stanozolol was found to cause severe cholestasis and ARF and the renal biopsy findings were consistent with resolving acute tubular necrosis. ARF as a complication of rhabdomyolysis in a body builder using AAS has also been reported. Furthermore, attention should also be paid to the possibility of interstitial nephritis as an adverse effect of AAS abuse.
Chronic hypovolaemia, may magnify renal damage processes or electrolytic disorders.
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